Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC012
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-28 12:03
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 4x1/4 caps Madopar a 125mg jedna uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 14, 'TP': 24, 'FP': 16}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 4, 'TN': 2, 'TP': 38, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.752
timePerCircleCoV 0.105753
timePerCircleSlope 0.000904568
meanError 2.44039
tremorFreq 7.51953
tremorRelPower 26.1536
tremorGyroAmpMean 0.0621561
tremorGyroAmpSlope -0.0745341
tremorGyroAmpCoV 0.779431
tremorCoordAmpMean 0.102888
tremorCoordAmpSlope -0.0489791
tremorCoordAmpCoV 0.687158
tremorAccAmpMean 0.0722781
tremorAccAmpSlope -0.0624436
tremorAccAmpCoV 0.780385
tremorPcRelVar 0.842617
tremorPcX 0.463212
tremorPcY -0.886247

Circle Segment 1

Duration 3.56 s, Accuracy Estimate 2.741 (lower is better)

Circle Segment 2

Duration 4.0 s, Accuracy Estimate 2.401 (lower is better)

Circle Segment 3

Duration 2.96 s, Accuracy Estimate 1.934 (lower is better)

Circle Segment 4

Duration 4.16 s, Accuracy Estimate 2.386 (lower is better)

Circle Segment 5

Duration 4.28 s, Accuracy Estimate 2.448 (lower is better)

Circle Segment 6

Duration 3.6 s, Accuracy Estimate 2.46 (lower is better)

Circle Segment 7

Duration 3.84 s, Accuracy Estimate 2.024 (lower is better)

Circle Segment 8

Duration 3.76 s, Accuracy Estimate 2.482 (lower is better)

Circle Segment 9

Duration 4.0 s, Accuracy Estimate 3.33 (lower is better)

Circle Segment 10

Duration 3.36 s, Accuracy Estimate 2.2 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 8.964
timePerSpiralCoV 0.125058
timePerSpiralSlope 0.0114397
meanError 2.37799
tremorFreq 5.85938
tremorRelPower 25.0331
tremorGyroAmpMean 0.0540149
tremorGyroAmpSlope 0.00602091
tremorGyroAmpCoV 0.51544
tremorCoordAmpMean 0.106384
tremorCoordAmpSlope 0.00512269
tremorCoordAmpCoV 0.454227
tremorAccAmpMean 0.0879047
tremorAccAmpSlope 0.00519953
tremorAccAmpCoV 0.390378
tremorPcRelVar 0.780544
tremorPcX 0.703652
tremorPcY -0.710544

Spiral Segment 1

Duration 8.08 s, Accuracy Estimate 2.398 (lower is better)

Spiral Segment 2

Duration 8.6 s, Accuracy Estimate 2.189 (lower is better)

Spiral Segment 3

Duration 9.96 s, Accuracy Estimate 2.166 (lower is better)

Spiral Segment 4

Duration 9.72 s, Accuracy Estimate 2.185 (lower is better)

Spiral Segment 5

Duration 8.88 s, Accuracy Estimate 2.633 (lower is better)

Spiral Segment 6

Duration 8.32 s, Accuracy Estimate 2.494 (lower is better)

Spiral Segment 7

Duration 7.24 s, Accuracy Estimate 2.482 (lower is better)

Spiral Segment 8

Duration 8.24 s, Accuracy Estimate 2.519 (lower is better)

Spiral Segment 9

Duration 9.48 s, Accuracy Estimate 2.63 (lower is better)

Spiral Segment 10

Duration 11.12 s, Accuracy Estimate 2.083 (lower is better)

Elel

eDurationMean 0.296351
eDurationStd 0.052117
eDurationStdnorm 0.175862
eDurationMedian 0.28
eDurationQuartdelta 0.065
eDurationQuartdeltanorm 0.232143
eDurationKurt 2.62925
eDurationTrenddiff 0.01
eDurationTrendratio 1.03636
eWidthMean 5.21757
eWidthStd 1.37512
eWidthStdnorm 0.263556
eWidthMedian 4.914
eWidthQuartdelta 1.49175
eWidthQuartdeltanorm 0.303571
eWidthKurt 4.46673
eWidthTrenddiff -0.8775
eWidthTrendratio 0.846939
eHeightMean 11.719
eHeightStd 1.86519
eHeightStdnorm 0.159159
eHeightMedian 11.583
eHeightQuartdelta 2.34
eHeightQuartdeltanorm 0.20202
eHeightKurt 2.63507
eHeightTrenddiff -0.351
eHeightTrendratio 0.970443
eAspectMean 0.456029
eAspectStd 0.140083
eAspectStdnorm 0.30718
eAspectMedian 0.446809
eAspectQuartdelta 0.138815
eAspectQuartdeltanorm 0.31068
eAspectKurt 3.95731
eAspectTrenddiff -0.0145242
eAspectTrendratio 0.968591
eSlantMean -0.0472874
eSlantStd 0.165672
eSlantStdnorm -3.50351
eSlantMedian -0.018018
eSlantQuartdelta 0.210394
eSlantQuartdeltanorm -11.6769
eSlantKurt 2.93225
eSlantTrenddiff -0.0142891
eRtopMean 0.773436
eRtopStd 0.175301
eRtopStdnorm 0.226652
eRtopMedian 0.8125
eRtopQuartdelta 0.192842
eRtopQuartdeltanorm 0.237344
eRtopKurt 4.11069
eRtopTrenddiff 0.111336
eRbotMean 0.879981
eRbotStd 0.281387
eRbotStdnorm 0.319764
eRbotMedian 0.921875
eRbotQuartdelta 0.448207
eRbotQuartdeltanorm 0.486191
eRbotKurt 2.16769
eRbotTrenddiff 0.185773
eRrightMean 0.899749
eRrightStd 0.0884347
eRrightStdnorm 0.0982882
eRrightMedian 0.927835
eRrightQuartdelta 0.113854
eRrightQuartdeltanorm 0.12271
eRrightKurt 2.88557
eRrightTrenddiff 0.0158814
eRleftMean 0.440021
eRleftStd 0.14364
eRleftStdnorm 0.326439
eRleftMedian 0.429907
eRleftQuartdelta 0.203873
eRleftQuartdeltanorm 0.474227
eRleftKurt 2.61227
eRleftTrenddiff -0.080253
lDurationMean 0.398065
lDurationStd 0.0574409
lDurationStdnorm 0.144301
lDurationMedian 0.38
lDurationQuartdelta 0.07125
lDurationQuartdeltanorm 0.1875
lDurationKurt 3.8998
lDurationTrenddiff -0.05
lDurationTrendratio 0.880952
lWidthMean 6.05003
lWidthStd 1.40016
lWidthStdnorm 0.23143
lWidthMedian 5.967
lWidthQuartdelta 1.872
lWidthQuartdeltanorm 0.313725
lWidthKurt 3.39965
lWidthTrenddiff -0.936
lWidthTrendratio 0.846154
lHeightMean 23.5812
lHeightStd 3.05694
lHeightStdnorm 0.129635
lHeightMedian 23.283
lHeightQuartdelta 4.8555
lHeightQuartdeltanorm 0.208543
lHeightKurt 2.37644
lHeightTrenddiff -4.329
lHeightTrendratio 0.833333
lAspectMean 0.259028
lAspectStd 0.0597654
lAspectStdnorm 0.230729
lAspectMedian 0.252427
lAspectQuartdelta 0.0786612
lAspectQuartdeltanorm 0.311619
lAspectKurt 3.8426
lAspectTrenddiff 0.0200083
lAspectTrendratio 1.08035
lSlantMean -0.0567867
lSlantStd 0.0904304
lSlantStdnorm -1.59246
lSlantMedian -0.0486486
lSlantQuartdelta 0.15731
lSlantQuartdeltanorm -3.2336
lSlantKurt 2.15497
lSlantTrenddiff -0.0554396
lRtopMean 0.670897
lRtopStd 0.177292
lRtopStdnorm 0.264261
lRtopMedian 0.692308
lRtopQuartdelta 0.151321
lRtopQuartdeltanorm 0.218575
lRtopKurt 4.58739
lRtopTrenddiff -0.025641
lRbotMean 0.928738
lRbotStd 0.335047
lRbotStdnorm 0.360755
lRbotMedian 0.876923
lRbotQuartdelta 0.398929
lRbotQuartdeltanorm 0.454919
lRbotKurt 2.83926
lRbotTrenddiff 0.0397436
lRrightMean 0.860039
lRrightStd 0.0847878
lRrightStdnorm 0.0985861
lRrightMedian 0.871795
lRrightQuartdelta 0.138126
lRrightQuartdeltanorm 0.158439
lRrightKurt 2.42265
lRrightTrenddiff 0.0389109
lRleftMean 0.493939
lRleftStd 0.19791
lRleftStdnorm 0.400676
lRleftMedian 0.507389
lRleftQuartdelta 0.287723
lRleftQuartdeltanorm 0.567065
lRleftKurt 2.83972
lRleftTrenddiff 0.116406

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.658964
sumTouchScores 18.451
meanMovementTime 0.707222
numTouches 28
undershootPercentage 3.57143
overshootPercentage 42.8571

FITTS Long Modified

meanTouchScore 0.686772
sumTouchScores 10.3016
meanMovementTime 1.36
numTouches 15
undershootPercentage 6.66667
overshootPercentage 26.6667

ZigZag

numZigzags 5
timePerZigzagMean 14.608
timePerZigzagCoV 0.0429648
timePerZigzagSlope 0.0161555
meanError 2.89289
tremorFreq 6.83594
tremorRelPower 22.8847
tremorGyroAmpMean 0.0575069
tremorGyroAmpSlope 0.00156446
tremorGyroAmpCoV 0.393667
tremorCoordAmpMean 0.111194
tremorCoordAmpSlope 0.000978263
tremorCoordAmpCoV 0.364102
tremorAccAmpMean 0.0922395
tremorAccAmpSlope 0.000697638
tremorAccAmpCoV 0.37705
tremorPcRelVar 0.704886
tremorPcX 0.419617
tremorPcY 0.907701

ZigZag Segment 1

Duration 14.36 s, Accuracy Estimate 2.712 (lower is better)

ZigZag Segment 2

Duration 14.64 s, Accuracy Estimate 3.165 (lower is better)

ZigZag Segment 3

Duration 13.96 s, Accuracy Estimate 2.803 (lower is better)

ZigZag Segment 4

Duration 14.44 s, Accuracy Estimate 2.526 (lower is better)

ZigZag Segment 5

Duration 15.64 s, Accuracy Estimate 3.26 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 12.7333
timePerZigzagCoV 0.127257
timePerZigzagSlope -0.0423635
zigzagHeightMean 63.2709
zigzagHeightCoV 0.0279924
zigzagHeightSlope 0.00535077
meanError 0.0409699
tremorFreq 6.25
tremorRelPower 25.8408
tremorGyroAmpMean 0.0670542
tremorGyroAmpSlope -0.00569665
tremorGyroAmpCoV 0.470962
tremorCoordAmpMean 0.137323
tremorCoordAmpSlope -0.000693189
tremorCoordAmpCoV 0.315527
tremorAccAmpMean 0.131219
tremorAccAmpSlope -0.000743832
tremorAccAmpCoV 0.240996
tremorPcRelVar 0.759607
tremorPcX 0.23822
tremorPcY -0.971211

ZigZag Offset Segment 1

Duration 12.72 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 2

Duration 14.76 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 3

Duration 13.08 s, Accuracy Estimate 0.052 (lower is better)

ZigZag Offset Segment 4

Duration 12.56 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 13.44 s, Accuracy Estimate 0.06 (lower is better)

ZigZag Offset Segment 6

Duration 9.84 s, Accuracy Estimate 0.053 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.85}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.45551586265631716}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8114814591559667}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.3774013278639012}